Tesofensine (500mcg) Tablets x30

Triple Reuptake Inhibition:

Tesofensine selectively blocks DAT, NET, and SERT, leading to significant increases in synaptic monoamine levels that influence appetite, mood, energy, and motivation [2][4]. 

Appetite Suppression & Weight Modulation:

Rodent and clinical studies document robust appetite suppression and dose-dependent fat mass reduction (~$6%–12%$ over 6 months), with early reports showing 20–23 lbs greater loss than placebo [2][3][5]. 

Energy Expenditure Enhancement:

Tesofensine increases basal energy expenditure and fat oxidation, contributing to improved metabolic efficiency even under caloric restriction [7][8]. 

Neurocognitive and Behavioral Effects:

Preclinical models show inhibition of hypothalamic GABA‑ergic circuits that regulate feeding, and early clinical data suggest potential cognitive and mood benefits via enhanced monoaminergic signaling [6][9]. 

Cardiovascular & Metabolic Markers:

Studies note slight increases in resting heart rate and blood pressure with tesofensine treatment—careful monitoring is advised in energy regulation research [5][7]. 

Citations

1. PubChem Compound Summary for Tesofensine (CID 11370864): molecular data—C₁₇H₂₃Cl₂NO; MW 328.3 Da. 
2. JAMA Neurology: “Tesofensine (NS2330), a Monoamine Reuptake Inhibitor …” Preclinical and early human pharmacology. 
3. The Lancet: Phase II clinical trial showing >20 lbs weight loss over 24 weeks and appetite-suppressant efficacy. 
4. ScienceDirect Topics overview: “Tesofensine is a novel triple monoamine reuptake inhibitor … induces weight loss primarily by reducing food intake …” 
5. PLOS ONE: “Tesofensine … silences GABAergic hypothalamic neurons,” demonstrating neuro-mechanistic appetite regulation. 
6. The Peptide Report: “Tesofensine influences neurotransmitter levels to support metabolic health and cognitive function.” 
7. HealthOn: Reports increased resting energy expenditure and metabolic rate during tesofensine use. 
8. Biology Insights: “Tesofensine Side Effects: Neurological and Beyond” — details metabolic and cardiovascular side-effects. 
9. PeptidesWiki: summarizing clinical trial outcomes in obesity, ADHD, and Parkinson's disease with neurobehavioral and safety data.