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Tesofensine (500mcg) Tablets x30

Tesofensine (500mcg) Tablets x30

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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

What is Tesofensine (500mcg) Tablets x30?

Tesofensine is a synthetic small-molecule monoamine reuptake inhibitor (MRI) that targets dopamine (DAT), norepinephrine (NET), and serotonin (SERT) transporters with high affinity, originating from the phenyltropane chemical class [1][2]. Initially developed for neurodegenerative research, it was later repurposed for metabolic and appetite studies due to its potent appetite-suppressant and adaptive energy-regulating effects [2][3]. In preclinical and clinical settings, tesofensine is used to investigate mechanisms of energy balance, neurotransmitter modulation, and metabolic adaptation.

Chemical Structure of Tesofensine (500mcg) Tablets x30

Chemically designated as (1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane, tesofensine has a molecular formula of C₁₇H₂₃Cl₂NO and a molecular weight of 328.3 Da, according to PubChem (CID 11370864) [1][4]. Its phenyltropane scaffold combines a dichlorophenyl ring with a bicyclic azabicyclo core and ethoxymethyl and methyl substituents, enabling efficient brain penetration and high-affinity transporter binding [1][2].

What Are the Effects of Tesofensine (500mcg) Tablets x30?

Triple Reuptake Inhibition:

Tesofensine selectively blocks DAT, NET, and SERT, leading to significant increases in synaptic monoamine levels that influence appetite, mood, energy, and motivation [2][4]. 

Appetite Suppression & Weight Modulation:

Rodent and clinical studies document robust appetite suppression and dose-dependent fat mass reduction (~$6%–12%$ over 6 months), with early reports showing 20–23 lbs greater loss than placebo [2][3][5]. 

Energy Expenditure Enhancement:

Tesofensine increases basal energy expenditure and fat oxidation, contributing to improved metabolic efficiency even under caloric restriction [7][8]. 

Neurocognitive and Behavioral Effects:

Preclinical models show inhibition of hypothalamic GABA‑ergic circuits that regulate feeding, and early clinical data suggest potential cognitive and mood benefits via enhanced monoaminergic signaling [6][9]. 

Cardiovascular & Metabolic Markers:

Studies note slight increases in resting heart rate and blood pressure with tesofensine treatment—careful monitoring is advised in energy regulation research [5][7]. 

Citations

  1. PubChem Compound Summary for Tesofensine (CID 11370864): molecular data—C₁₇H₂₃Cl₂NO; MW 328.3 Da. 
  2. JAMA Neurology: “Tesofensine (NS2330), a Monoamine Reuptake Inhibitor …” Preclinical and early human pharmacology. 
  3. The Lancet: Phase II clinical trial showing >20 lbs weight loss over 24 weeks and appetite-suppressant efficacy. 
  4. ScienceDirect Topics overview: “Tesofensine is a novel triple monoamine reuptake inhibitor … induces weight loss primarily by reducing food intake …” 
  5. PLOS ONE: “Tesofensine … silences GABAergic hypothalamic neurons,” demonstrating neuro-mechanistic appetite regulation. 
  6. The Peptide Report: “Tesofensine influences neurotransmitter levels to support metabolic health and cognitive function.” 
  7. HealthOn: Reports increased resting energy expenditure and metabolic rate during tesofensine use. 
  8. Biology Insights: “Tesofensine Side Effects: Neurological and Beyond” — details metabolic and cardiovascular side-effects. 
  9. PeptidesWiki: summarizing clinical trial outcomes in obesity, ADHD, and Parkinson's disease with neurobehavioral and safety data. 

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Product Quality Guarantee

We are continuously conducting HPLC test on all of our raw powders as well as finished products to ensure the quality of our products. You can have the product you bought from us tested at any HPLC licensed testing facility and if the results are negative, we will refund the following:
HPLC TEST FEE
$100
PLUS Total amount of the Order + Shipping Fee

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

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