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Semax (5mg) 2ml Vial

Semax (5mg) 2ml Vial

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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

What is Semax (5mg) 2ml Vial?

Semax is a synthetic heptapeptide analogue derived from the ACTH (4–10) fragment, containing the sequence Met–Glu–His–Phe–Pro–Gly–Pro (MEHFPGP) [1]. Originally developed in Russia during the 1980s, it was engineered to enhance metabolic stability and neuroactive properties—effectively bypassing the hormonal activity of full-length ACTH while retaining central nervous action [2][4].

Chemical Structure of Semax (5mg) 2ml Vial

Semax’s primary structure consists of the seven amino acids Met–Glu–His–Phe–Pro–Gly–Pro, with chemical formula C₃₇H₅₁N₉O₁₀S and an average molecular weight of 813.9 Da, as confirmed by PubChem (CID 122178) [1][3]. It incorporates a C-terminal Pro‑Gly‑Pro tripeptide (PGP) to enhance resistance to enzymatic degradation, ensuring prolonged neuropeptide activity in experimental models [6].

What Are the Effects of Semax (5mg) 2ml Vial?

Neuroprotective & Gene Expression Modulation:

In rodent stroke models, Semax reduces inflammatory gene expression (e.g., MMP-9, c-Fos, JNK), upregulates CREB and BDNF, and supports neuron survival in ischemic penumbra [4][5]. 

Cognitive Enhancement & BDNF Elevation:

A single dose significantly increases BDNF protein and mRNA in the hippocampus (~1.4×), with corresponding gains in learning and memory performance in preclinical models [2][6]. 

Monoaminergic System Support:

Studies report Semax enhances dopamine and serotonin transmission in the striatum and cortex, facilitating neurobehavioral resilience [7]. 

Immunomodulation & Angiogenesis:

In ischemic rodent models, Semax shifts expression of immune-regulating chemokines and immunoglobulins, and supports angiogenic gene expression to promote vascular recovery [4]. 

Nootropic & Default Mode Network Effects:

Functional MRI in humans demonstrates Semax alters default mode network activity, linked to enhanced cortical connectivity and attentional processing [8]. 

Citations

  1. PubChem Compound Summary for Semax (CID 122178): sequence MEHFPGP; formula C₃₇H₅₁N₉O₁₀S; MW 813.9 Da. 
  2. Dolotov OV, et al. “Semax, an analog of ACTH(4–10), induces expression of BDNF in rat brain.” Neurosci Lett. 2006;403(1–2):170–175. PMID: 16750888. 
  3. PubChem record confirming sequence and molecular data. 
  4. Sharifulina SA, et al. “Semax modulates expression profiles of genes involved in immunity and vascular response in rat focal brain ischemia.” BMC Genomics. 2014;15:228. PMID: 24886652. 
  5. Semax suppresses MMP-9, c-Fos, JNK and activates CREB in ischemia model. Int J Mol Sci. 2021;22(12):6179. 
  6. Shatskova OL, et al. “Semax administration increases hippocampal BDNF and improves performance in learning tests.” Bull Exp Biol Med. 2006;141(6):637–640. PMID: 17200307. 
  7. Neurochemical analyses show Semax enhances dopamine and serotonin systems. Dokl Biol Sci. 2005;403(1–2):148–152. PMID: 16182730. 
  8. Lebedeva IS, et al. “Effects of Semax on the default mode network in healthy volunteers.” Bull Exp Biol Med. 2018;165(5):653–656. PMID: 30225715. 

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Product Quality Guarantee

We are continuously conducting HPLC test on all of our raw powders as well as finished products to ensure the quality of our products. You can have the product you bought from us tested at any HPLC licensed testing facility and if the results are negative, we will refund the following:
HPLC TEST FEE
$100
PLUS Total amount of the Order + Shipping Fee

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

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