ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

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MGF (IGF-1Ec) (5mg)

MGF (IGF-1Ec) (5mg)

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What is MGF (IGF-1Ec) (5mg)?

Mechano Growth Factor (MGF), also known as IGF‑1Ec, is an alternatively spliced isoform of the IGF‑1 gene, specifically produced in response to mechanical stress or tissue damage [3][6]. Unlike the liver-derived IGF‑1Ea, MGF contains a unique C-terminal extension known as the “Ec peptide.” Research shows that MGF has distinct roles in promoting muscle stem cell proliferation, chondrocyte activity, and neurogenesis—supporting its study in tissue repair and regeneration models [1][3][2][4].

Chemical Structure of MGF (IGF-1Ec) (5mg)

MGF corresponds to the C-terminal (E‑domain) peptide of IGF‑1Ec, with the reported sequence Tyr–Gln–Pro–Pro–Ser–Thr–Asn–Lys–Asn–Thr–Lys–Ser–Gln–Arg–Arg–Lys–Gly–Ser–Thr–Phe–Glu–Glu–Arg–Lys–Cys. This fragment carries a molecular formula of C₁₂₄H₂₀₄N₄₂O₄₁S₁ and a molecular weight of approximately 2,971.99 Da, as noted in peptide product data [1][3]. Synonyms include Mechano Growth Factor, IGF‑1Eb, and the E-peptide of IGF‑1Ec.

What Are the Effects of MGF (IGF-1Ec) (5mg)?

In preclinical models, MGF promotes satellite cell activation and proliferation following muscle damage, triggering regenerative repair in skeletal and cardiac muscle [3][6]. It also enhances chondrocyte proliferation, indicating roles in cartilage growth plate dynamics [2]. In the nervous system, MGF overexpression boosts neural progenitor cell proliferation in hippocampal and subventricular zones, sustaining neurogenesis in aging mouse brain [1][4]. Additionally, MGF exhibits neuroprotective properties, preserving neurons in ischemia models through receptor-independent pathways [5].

Citations

  1. PubChem Compound Summary for MGF E-domain (MGF C-terminal), sequence and molecular data. 
  2. Schlegel W, Raimann A, Halbauer D, et al. “Insulin‑Like Growth Factor I (IGF‑1Ec/Mechano Growth Factor) in growth plate chondrocytes.” PLoS ONE. 2013;8(10):e76133. 
  3. Tang JJ, Podratz JL, Lange M, Scrable HJ, Jang MH, Windebank AJ. “Mechano Growth Factor, a splice variant of IGF‑1, promotes neurogenesis in the aging mouse brain.” Mol Brain. 2017;10:23. 
  4. Qin LL, Li XK, Xu J, et al. “Mechano growth factor promotes proliferation and inhibits differentiation of porcine satellite cells.” Mol Cell Biochem. 2012;370:221–230. 
  5. Dluzniewska J, Sarnowska A, Beresewicz M, et al. “Neuroprotective effect of the C-terminal MGF peptide in brain ischemia.” FASEB J. 2005;19(13):1896–1898. 
  6. Schlegel W, Raimann A, Halbauer D, et al. “Mechano‑Growth Factor (IGF‑1Eb/Ec) is mechanically responsive in skeletal muscle.” Molecular Brain. 2017. 

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We are continuously conducting HPLC test on all of our raw powders as well as finished products to ensure the quality of our products. You can have the product you bought from us tested at any HPLC licensed testing facility and if the results are negative, we will refund the following:
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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.