ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

1 1

HCG (5000iu)

HCG (5000iu)

As low as $54 each!
$60.00
$60.00
Sale Sold out
Shipping calculated at checkout.
  • FREE SHIPPING
  • 99%+ PURITY
  • MADE IN USA
View full details

What is HCG (5000iu)?

Human chorionic gonadotropin (HCG) is a naturally occurring placental glycoprotein hormone that interacts with the luteinizing hormone/choriogonadotropin receptor (LHCGR). It is structured as a disulfide-rich heterodimer comprising a common 92-amino-acid alpha subunit and a unique 145-amino-acid beta subunit, which confer receptor specificity [1][2]. In preclinical research, HCGis used to explore luteinizing hormone receptor signaling, reproductive endocrinology, paracrine crosstalk, and angiogenic pathways.

Chemical Structure of HCG (5000iu)

HCG is a heterodimeric glycoprotein (~37.9 kDa molecular mass, ~30% carbohydrate by weight) composed of: 

  • Alpha subunit: 92 amino acids, shared among LH, FSH, TSH, and HCG. 
  • Beta subunit: 145 amino acids, which includes a unique 24-residue C‑terminal peptide (CTP) that provides structural specificity and a prolonged half-life [2][8]. 
  • Eight carbohydrate chains (two N‑linked on α, two N‑linked plus four O‑linked on β) that enhance stability and bioavailability [2][9]. 

Both subunits feature a cystine‑knot motif formed by three disulfide bonds, establishing a rigid tertiary structure essential for receptor activation [1][8]. 

What Are the Effects of HCG (5000iu)?

LHCGR-Mediated Signaling:

Upon binding LHCGR, HCG activates Gs and Gq pathways, leading to cyclic AMP production and downstream steroidogenesis in gonadotrophin-responsive cells [1][2]. 

Angiogenic and Paracrine Effects:

HCG stimulates endothelial cells to produce angiogenic factors during early placentation stages in vitro, including VEGF-mediated pathways [6]. 

Reproductive Endocrine Modulation:

In preclinical studies, HCG signaling enhances progesterone secretion through corpus luteum support and influences oocyte maturation in granulosa cells [5]. 

Biased Agonism and Differentiated Signaling:

Comparative studies reveal HCG triggers distinct intracellular signaling and kinetics compared to LH, displaying unique LHCGR-mediated responses in cAMP production and gene expression [1][3]. 

Citations

  1. RCSB PDB – “Structure of human chorionic gonadotropin at 2.6 Å resolution: disulfide-rich heterodimer with cystine‑knot fold.” 1994. PMID: 7922031. 
  2. Sigma-Aldrich Product Sheet – “Human chorionic gonadotropin (HCG): glycoprotein heterodimer (~37.9 kDa), α (92 aa), β (145 aa), ~30% carbohydrate content.” 2002. 
  3. Frontiers in Immunology – “HCG induces angiogenic responses via LHCGR activation on endothelial and epithelial cells of the endometrium.” 2020. PMID: 32043617. 
  4. MDPI Int. J. Mol. Sci. – “HCG and its receptor LHCGR are expressed in reproductive tissues; HCG promotes oocyte maturation and early embryo development.” 2017;18(5):1059. PMID: 28538623. 
  5. Reproductive Biology and Endocrinology – “Biological functions of HCG variants; HCG binds LHCGR with ~37-hour half-life vs LH’s ~30 minutes.” 2010;8:102. PMID: 20579385. 
  6. Cell/Structure – “Three-dimensional structure shows cystine‑knot motif; β-subunit wraps α-subunit, stabilized by disulfide Cys26–Cys110.” 1994. 

COA

Certificate of Analysis

HPLC

High Performance Liquid Chromatography

High Quality - 99% Purity Guaranteed

Product Quality Guarantee

We are continuously conducting HPLC test on all of our raw powders as well as finished products to ensure the quality of our products. You can have the product you bought from us tested at any HPLC licensed testing facility and if the results are negative, we will refund the following:
HPLC TEST FEE
$100
PLUS Total amount of the Order + Shipping Fee

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

Customer Reviews

Be the first to write a review
0%
(0)
0%
(0)
0%
(0)
0%
(0)
0%
(0)