GHRP-2 (5mg)

What is GHRP‑2?

GHRP‑2 (Growth Hormone–Releasing Peptide‑2), also known as Pralmorelin or KP‑102, is a synthetic hexapeptide derived from met‑enkephalin analogues containing D‑amino acids. It acts as a ghrelin receptor (GHS‑R1a) agonist and stimulates growth hormone release from the pituitary gland in laboratory models. GHRP‑2 is widely studied for GH deficiency diagnostics and other endocrine applications.

Chemical Structure of GHRP‑2

The peptide sequence of GHRP‑2 is D‑Ala‑D‑2‑Nal‑Ala‑Trp‑D‑Phe‑Lys‑NH₂, with a molecular formula of C₄₅H₅₅N₉O₆ and an approximate molecular weight of 818 Da. It incorporates non-natural D‑amino acids and a naphthylalanine residue for enhanced receptor binding and stability.

What Are the Effects of GHRP‑2?

• Growth Hormone Stimulation: GHRP‑2 triggers strong, dose-dependent GH release by activating GHS‑R1a receptors on pituitary and hypothalamic cells. This response is amplified when combined with GHRH analogues.
• cAMP and Calcium Signaling: In ovine somatotroph cultures, GHRP‑2 increases intracellular cAMP and promotes GH secretion via calcium-dependent pathways, indicating a unique mechanism distinct from GHRP‑6.
• Appetite Stimulation: Human studies show GHRP‑2 increases food intake by activating ghrelin receptors, resulting in approximately 36% higher calorie intake compared to placebo.
• Endocrine Modulation: In addition to GH, GHRP‑2 modestly elevates prolactin, ACTH, and cortisol levels, indicating its influence on broader pituitary hormone pathways.
• Anti-inflammatory Effects: In murine models, co-administration of GHRP‑2 with LPS reduces expression of inflammatory genes such as TNF‑α, IL‑6, and iNOS in liver tissue.

Citations

1. PubChem Compound Summary – Pralmorelin (GHRP‑2): peptide sequence, MW, and structure Overview of GHRP‑2
2. Peptides.Guide: “GHRP‑2 Profile – GH Secretagogue and Ghrelin Mimetic” Overview of GHRP‑2
3. Bowers CY, et al. “GHRP‑2 increases food intake in healthy men” – J Clin Endocrinol Metab Overview of GHRP‑2
4. Arvat E, et al. “Endocrine effects of GHRP‑2 and Hexarelin” – Peptides Overview of GHRP‑2
5. Wu D, et al. “GHRP‑2 induces cAMP and GH secretion in ovine and rat somatotrophs” – J Endocrinol Overview of GHRP‑2
6. Abrehdari Z, et al. “GHRP‑2 reduces liver inflammation in LPS-challenged mice” – Comp Clin Pathol Overview of GHRP‑2