GHRP-2 (5mg)

What is GHRP‑2?

GHRP‑2 (Growth Hormone-Releasing Peptide‑2), also known as Pralmorelin or KP‑102, is a synthetic hexapeptide derived from met‑enkephalin analogues with D‑amino acids. It functions as a ghrelin receptor (GHS‑R1a) agonist and stimulates growth hormone release from the pituitary gland in laboratory settings. GHRP‑2 is actively studied as a diagnostic tool for GH deficiency and in various endocrine research models.

Chemical Structure of GHRP‑2

GHRP‑2’s sequence is D‑Ala‑D‑2‑Nal‑Ala‑Trp‑D‑Phe‑Lys‑NH₂, with an approximate molecular weight of 818 Da and formula C₄₅H₅₅N₉O₆. This hexapeptide incorporates unnatural D‑amino acids and a naphthylalanine side chain, enhancing receptor affinity and metabolic stability. .

What Are the Effects of GHRP‑2?

• Growth Hormone Stimulation: GHRP‑2 triggers strong, dose-dependent GH release by activating GHS‑R1a receptors on pituitary and hypothalamic cells. This response is amplified when combined with GHRH analogues.
• cAMP and Calcium Signaling: In ovine somatotroph cultures, GHRP‑2 increases intracellular cAMP and promotes GH secretion via calcium-dependent pathways, indicating a unique mechanism distinct from GHRP‑6.
• Appetite Stimulation: Human studies show GHRP‑2 increases food intake by activating ghrelin receptors, resulting in approximately 36% higher calorie intake compared to placebo.
• Endocrine Modulation: In addition to GH, GHRP‑2 modestly elevates prolactin, ACTH, and cortisol levels, indicating its influence on broader pituitary hormone pathways.
• Anti-inflammatory Effects: In murine models, co-administration of GHRP‑2 with LPS reduces expression of inflammatory genes such as TNF‑α, IL‑6, and iNOS in liver tissue.

Citations

1. PubChem Compound Summary – Pralmorelin (GHRP‑2): peptide sequence, MW, and structure Overview of GHRP‑2
2. Peptides.Guide: “GHRP‑2 Profile – GH Secretagogue and Ghrelin Mimetic” Overview of GHRP‑2
3. Bowers CY, et al. “GHRP‑2 increases food intake in healthy men” – J Clin Endocrinol Metab Overview of GHRP‑2
4. Arvat E, et al. “Endocrine effects of GHRP‑2 and Hexarelin” – Peptides Overview of GHRP‑2
5. Wu D, et al. “GHRP‑2 induces cAMP and GH secretion in ovine and rat somatotrophs” – J Endocrinol Overview of GHRP‑2
6. Abrehdari Z, et al. “GHRP‑2 reduces liver inflammation in LPS-challenged mice” – Comp Clin Pathol Overview of GHRP‑2