ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

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GHRP-2 (5mg)

GHRP-2 (5mg)

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What is GHRP-2 (5mg)?

GHRP‑2 (Growth Hormone‑Releasing Peptide‑2), also known as Pralmorelin or KP‑102, is a synthetic hexapeptide derived from met‑enkephalin analogues with D‑amino acids [1][2]. It functions as a ghrelin receptor (GHS‑R1a) agonist and stimulates growth hormone release from the pituitary gland in laboratory settings. GHRP‑2 is actively studied as a diagnostic tool for GH deficiency and in various endocrine research models [3].

Chemical Structure of GHRP-2 (5mg)

GHRP‑2’s sequence is D‑Ala‑D‑2‑Nal‑Ala‑Trp‑D‑Phe‑Lys‑NH₂, with an approximate molecular weight of 818 Da and formula C₄₅H₅₅N₉O₆ [1]. This hexapeptide incorporates unnatural D‑amino acids and a naphthylalanine side chain, enhancing receptor affinity and metabolic stability [2].

What Are the Effects of GHRP-2 (5mg)?

Growth-Hormone Stimulation:

GHRP‑2 triggers robust, dose-dependent GH release in vitro and in vivo by activating GHS‑R1a on pituitary and hypothalamic cells; this response is potentiated by GHRH analogues [4][5]. 

cAMP Signaling & Calcium Mobilization:

In sheep somatotroph cultures, GHRP‑2 elevates intracellular cAMP and induces GH secretion through a calcium-dependent pathway—unlike GHRP‑6—which suggests distinct mechanistic properties [5]. 

Appetite and Food Intake:

GHRP‑2 increases food consumption via ghrelin-receptor activation, demonstrated by ~36% higher calorie intake in human infusion studies compared to placebo [3]. 

Endocrine Modulation:

It also induces modest elevations in prolactin, ACTH, and cortisol in human subjects, indicating broader pituitary axis engagement [4]. 

Anti-inflammatory Effects:

In mouse liver challenged with LPS, GHRP‑2 reduced inflammatory gene expression (TNF‑α, IL‑6, iNOS), suggesting potential anti-inflammatory pathways in research models [6]. 

Citations

  1. PubChem Compound Summary for Pralmorelin (CID 6918245): D‑Ala‑D‑2‑Nal‑Ala‑Trp‑D‑Phe‑Lys‑NH₂; formula C₄₅H₅₅N₉O₆; MW 818 Da. 
  2. GHRP‑2 is a synthetic met‑enkephalin analogue and a potent secretagogue for GH release via ghrelin receptor agonism. Peptides.guide GHRP‑2 Profile. 
  3. Bowers CY, et al. “Growth Hormone Releasing Peptide‑2 (GHRP‑2), Like Ghrelin, Increases Food Intake in Healthy Men.” J Clin Endocrinol Metab. 2005;90(2):611–614. PMID: 15531345. 
  4. Arvat E, Di Vito L, Maccagno B, Broglio F, et al. “Effects of GHRP‑2 and Hexarelin on GH, prolactin, ACTH and cortisol levels in man.” Peptides. 1997;18(6):885–891. PMID: 9273351. 
  5. Wu D, Chen C, Zhang J, Bowers CY, Clarke IJ. “Effects of GHRP‑2 on intracellular cAMP and GH secretion in ovine and rat somatotrophs.” J Endocrinol. 1996;148(2):197–205. PMID: 8741792. 
  6. Abrehdari Z, Zendehdel M, Safarpour E, Allahdini P. “Co‑administration of GHRP‑2 reduces TNF‑α, IL‑6, and iNOS expression in LPS‑induced mouse liver.” Comp Clin Pathol. 2014;23:835–840. PMID: 24552647. 

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We are continuously conducting HPLC test on all of our raw powders as well as finished products to ensure the quality of our products. You can have the product you bought from us tested at any HPLC licensed testing facility and if the results are negative, we will refund the following:
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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.