ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

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FOXO4-DRI (15mg)

FOXO4-DRI (15mg)

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What is FOXO4-DRI (15mg)?

FOXO4-DRI (D-Retro-Inverso) is a synthetic, cell-permeable peptide designed to disrupt the interaction between the FOXO4 protein and the tumor suppressor p53. FOXO4-DRI disrupts this interaction, triggering apoptosis in senescent cells that contribute to aging and a range of age-related diseases. This mechanism positions FOXO4-DRI as a potential therapeutic agent in the field of regenerative medicine and anti-aging research.

Chemical Structure of FOXO4-DRI (15mg)

  • The “DRI” in its name refers to D-Retro-Inverso peptide design: the peptide is composed of D-amino acids in reversed sequence order compared to the original L-amino acid peptide, which increases proteolytic stability and often improves pharmacokinetic properties.
  • It comprises a FOXO4-derived region corresponding to its p53-interaction domain, coupled with cell-penetrating features. In binding studies, it mimics the binding site of FOXO4 (the forkhead domain) to p53’s Transactivation Domain (TAD), especially TAD2.
  • Recent NMR structural studies show that FOXO4-DRI is intrinsically disordered in solution but upon binding p53’s TAD2 region, a transiently folded complex is formed. This involves both hydrophobic and electrostatic interactions.

What Are the Effects of FOXO4-DRI (15mg)?

  • Selectively induces apoptosis in senescent cells by promoting nuclear exclusion of phosphorylated p53 (p53-pS15). [1,5]
  • Restores tissue homeostasis and improves various age-related conditions. [5]
  • In aged mice, alleviates age-related testosterone secretion insufficiency by improving the testicular microenvironment. [3]
  • Enhances spermatogenesis and sperm quality in aged mice. [4]
  • In keloid fibroblasts, induces apoptosis by promoting nuclear exclusion of upregulated p53-pS15, offering a potential approach to prevent keloid aggressiveness and relapse. [2]

Citations

  1. Huang, Y., et al. (2021). "Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells." PMC.
  2. Kong, Y.-X., et al. (2025). "FOXO4-DRI Induces Keloid Senescent Fibroblast Apoptosis by Promoting Nuclear Exclusion of Upregulated p53-Serine 15 Phosphorylation." Communications Biology.
  3. Zhang, C., et al. (2020). "FOXO4-DRI Alleviates Age-Related Testosterone Secretion Insufficiency in Naturally Aged Mice." PMC.
  4. Li, Y., et al. (2024). "FOXO4-DRI Improves Spermatogenesis in Aged Mice." ScienceDirect.
  5. Li, H., et al. (2017). "Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging." Cell.







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We are continuously conducting HPLC test on all of our raw powders as well as finished products to ensure the quality of our products. You can have the product you bought from us tested at any HPLC licensed testing facility and if the results are negative, we will refund the following:
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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

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