Brain Blend - Dihexa (10mg) / Tesofensine (250mcg) / BPC-157 (125mcg) x 60 Tablets

What is Brain Blend?

Brain Blend combines three research-focused compounds—Dihexa, Tesofensine, and BPC‑157—into a multidimensional investigational formulation aimed at studying neurotrophic support, neurotransmitter regulation, and regenerative processes:

• Dihexa: An oligopeptide derivative of angiotensin IV that binds hepatocyte growth factor (HGF) with femtomolar affinity, enhancing HGF/c‑Met signaling. Shown in animal models to boost synaptogenesis and cognitive performance—more potent than BDNF in neurotrophic assays.
• Tesofensine: A phenyltropane-based triple monoamine reuptake inhibitor (DAT, SERT, NET), originally studied for neurodegenerative conditions. It increases synaptic dopamine, serotonin, and norepinephrine, influencing neuronal signaling and energy metabolism.
• BPC‑157: A 15–amino-acid peptide derived from human gastric juice. Known in preclinical models for angiogenesis, cytoprotection, and tissue regeneration via VEGF and fibroblast activation pathways.

This blend allows preclinical researchers to evaluate the combined effects of neurotrophic signaling, neurotransmitter modulation, and tissue repair support within neurobiological models.

Chemical Structure of Brain Blend

This section provides a brief chemical profile for each compound:

• Dihexa: Molecular formula C₂₇H₄₄N₄O₅, monoisotopic mass ~504 Da; hexanoyl–Tyr–Ile–hexanoyl amide structure.
• Tesofensine: (1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane; formula C₁₇H₂₃Cl₂NO; mass ~328 Da.
• BPC‑157: Sequence: Gly–Glu–Pro–Pro–Pro–Gly–Lys–Pro–Ala–Asp–Asp–Ala–Gly–Leu–Val; formula C₆₂H₉₈N₁₆O₂₂; monoisotopic mass ~1,419.5 Da.

What Are the Effects of Brain Blend?

• Neurotrophic & Synaptogenic Activity: Dihexa activates HGF/c‑Met signaling and supports hippocampal synapse formation and cognitive enhancement in preclinical Alzheimer models—outperforming BDNF in potency.
• Monoamine Neurotransmission Modulation: Tesofensine elevates dopamine, serotonin, and norepinephrine levels. Studies show enhanced BDNF expression, improved neuroplasticity, and increased neuronal signaling.
• Angiogenic & Cytoprotective Actions: BPC‑157 upregulates VEGF and FGF‑2, promoting blood vessel growth, fibroblast repair, and neuroprotection in neural injury models.
• Neuroregenerative Synergy: The combination supports exploration of synergistic pathways for brain regeneration by combining synaptogenesis (Dihexa), neurotransmitter amplification (Tesofensine), and vascular/tissue protection (BPC‑157).

Citations

1. NCATS Inxight Drugs – Dihexa potentiates HGF/c‑Met activity; improves cognition and synapse formation in rat models. Brain Blend Overview
2. PeptidesWiki: Dihexa binds HGF with high affinity, promotes synaptogenesis and cognitive improvement via c‑Met signaling. Brain Blend Overview
3. PubChem – Tesofensine (CID 11370864): triple monoamine reuptake inhibitor; formula C₁₇H₂₃Cl₂NO; MW ~328 Da. Brain Blend Overview
4. ScienceDirect – Tesofensine inhibits DAT, NET, SERT; increases monoaminergic signaling and BDNF expression. Brain Blend Overview
5. PubChem – BPC‑157 (CID 9941957): pentadecapeptide; sequence and formula confirmed. Brain Blend Overview
6. ScienceDirect – “The pentadecapeptide BPC157… demonstrated obvious protective effects on tissue.” Brain Blend Overview
7. ChemSpider – Dihexa (CID 57582587): confirms molecular formula and structure. Brain Blend Overview