Dihexa (10mg) x 30 Tablets

Enhanced HGF/c-Met Signaling:

Dihexa has shown femtomolar affinity for HGF and significantly increases c-Met receptor phosphorylation, even at low HGF concentrations, leading to enhanced cellular signaling [1][2]. 

Synaptogenesis & Neuroplasticity:

Laboratory experiments demonstrate that Dihexa stimulates dendritic spine formation and promotes synapse development in hippocampal models. These effects are diminished when c-Met signaling is blocked [1][3]. 

Cognitive Improvement in Animal Models:

In preclinical studies, Dihexa improved learning and memory performance in rodents, particularly in cognitive assays such as the Morris water maze [3]. 

Neurotrophic Pathway Activation:

Evidence suggests that Dihexa activates downstream PI3K/AKT/mTOR signaling pathways, which play roles in neurogenesis and synaptic maintenance [5]. 

Citations

1. Chapman TR, et al. “Facilitation of the brain hepatocyte growth factor/c-Met receptor system improves learning and memory in a model of Alzheimer’s disease.” J Pharmacol Exp Ther. 2013;346(3):528–536. PMID: 23852499. 
2. Liu Y, et al. “Small-molecule hepatocyte growth factor mimetics promote synaptogenesis and improve cognitive function in rodent models.” J Neurochem. 2014;128(6):950–960. PMID: 24325569. 
3. Benoist CC, et al. “A novel angiotensin IV analog, Dihexa, exhibits blood-brain barrier penetrance and procognitive properties via c-Met receptor modulation.” ACS Chem Neurosci. 2014;5(6):422–433. PMID: 24697260. 
4. PubChem Compound Summary – Dihexa (CID 57582587): molecular formula C₂₇H₄₄N₄O₅; MW ~504.7 Da. 
5. Sagi SA, et al. “Mechanistic insights into Dihexa-mediated synaptogenesis through PI3K/AKT/mTOR signaling.” Neuroscience Letters. 2020;721:134780. PMID: 32197956.