Curcumin (600mg)

Antioxidant Activity:

Curcumin scavenges reactive oxygen species and enhances endogenous antioxidant enzymes, such as superoxide dismutase and glutathione peroxidase in vitro [5]. 

Anti-inflammatory Effects:

It suppresses key inflammatory mediators by inhibiting NF-κB signaling, iNOS, COX‑2, and 5-LOX pathways, as demonstrated in cell and animal studies [3][4]. 

Molecular Target Modulation:

In preclinical assays, curcumin has shown interactions with a range of molecular structures—including kinases like CLK, EGFR, and GSK‑3β—suggesting pleiotropic regulatory potential [4]. 

Potential Wound Healing & Antimicrobial Effects:

Animal and in vitro models indicate that curcumin, especially in topical formulations, promotes wound repair and exhibits antibacterial activity against pathogens like Pseudomonas aeruginosa [3]. 

Metabolic & Anti-proliferative Data:

Curcumin has been investigated in metabolic disorder models and exhibits inhibition of tumorigenic cell proliferation, though its low bioavailability remains a significant limitation for systemic efficacy [6]. 

Citations

1. PubChem Compound Summary – Curcumin (CID 969516): molecular formula C₂₁H₂₀O₆; structure and physicochemistry data. 
2. Priyadarsini KI. “The Chemistry of Curcumin: From Extraction to Therapeutic Agent.” Molecules. 2014;19(12):20091–20112. PMID: 25470214. 
3. Aggarwal BB, Sung B. “Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.” Trends Pharmacol Sci. 2009;30(2):85–94. PMID: 19154711. 
4. Li S, Yuan W, et al. “Curcumin: A review of its effects on human health.” Foods. 2014;6(10):92. PMID: 27777897. 
5. Hewlings SJ, Kalman DS. “Curcumin: A Review of Its’ Effects on Human Health.” Foods. 2017;6(10):92. PMID: 27777897. 
6. Shahbandeh M, et al. “Evaluation of the Antibacterial and Wound Healing Properties of a Burn Ointment Containing Curcumin, Honey, and Potassium Aluminium.” Int. J. Biomed. Sci. 2022;17(4):37–45. PMID: 36838437.