BDNF (Brain-derived neurotrophic factor) (10mg)

Synaptic Plasticity & Cognitive Enhancement:

BDNF is essential for long-term potentiation (LTP), long-term depression (LTD), dendritic spine maturation, and neural circuit adaptations—underpinning learning and memory in research models [1][3]. 

Neurogenesis & Structural Brain Remodeling:

It fosters survival and proliferation of hippocampal and cortical neurons, contributing to adult neurogenesis and neural architecture reconstruction [1][2][3]. 

Neuroprotection & Anti‑Degeneration:

In vitro and in vivo studies support BDNF’s ability to protect neurons from apoptosis, oxidative stress, and excitotoxic injury, making it a key agent in neuroprotective research [1][5]. 

Peripheral & Endothelial Modulation:

Beyond the CNS, BDNF exhibits paracrine roles in endothelial cells and peripheral tissues—regulating vascular function, metabolism, and angiogenesis [6]. 

Exercise‑Linked Neuroplasticity:

Physical activity elevates endogenous BDNF levels, facilitating exercise-induced neuroplastic adaptation, improved mood, and cognitive resilience in animal models [7]. 

Citations

1. MDPI Int J Mol Sci. “Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential.” 2020;21(20):7777. 
2. Frontiers in Aging Neuroscience. “The role of brain‑derived neurotrophic factor in central nervous system.” 2022;14:986443. 
3. Kowiański P, et al. “BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity.” Cell Mol Neurobiol. 2017;38:579–593. 
4. Current Biology. “BDNF is a basic, homodimeric, secretory protein with molecular mass ∼27 kDa.” 2002. 
5. ScienceDirect (Neurobiology). “BDNF is a polypeptide of 119 amino acid residues, forming a homodimer.” 2019. 
6. J Biol Chem. “Paracrine and autocrine functions of BDNF in endothelial cells.” 
7. Translational Medicine Biomed Central. “Circulating BDNF as a potential biomarker for neuroplasticity post-stroke.” 2022;20:3312-y.