3X Blend Tesamorelin (5mg) / MGF (500mcg) / Ipamorelin (2.5mg)

This 3X Blend combines three distinct peptides—Tesamorelin (5 mg), MGF (Mechano-Growth Factor, 500 mcg), and Ipamorelin (2.5 mg)—crafted for preclinical research into synergistic growth hormone axis activation, tissue repair, and metabolic regulation. 

• Tesamorelin is a 44–amino-acid GHRH analogue with a trans‑3‑hexenoic acid N‑terminal modification, used to initiate physiological, pulsatile GH release through GHRH-receptor engagement [1][2]. 
• MGF is the C‑terminal E‑domain peptide of IGF‑1Ec, encoded via alternative splicing. It is released in response to mechanical stress and stimulates satellite cell activation, muscle repair, and tissue regeneration via IGF‑1 receptor–independent pathways, often engaging ERK signaling [3][4]. 
• Ipamorelin is a selective ghrelin receptor agonist pentapeptide (sequence Aib–His–D‑2‑Nal–D‑Phe–Lys–NH₂) that promotes endogenous GH release without affecting cortisol or prolactin [5][6]. 

By uniting GHRH, ghrelin receptor, and MGF E-domain–associated effects, this triple formulation provides a multimechanistic approach to studying endogenous GH secretion, muscle remodeling, and regenerative signaling in research models. 

Citations 

1. PubChem Compound Summary for Tesamorelin (CID 146681838): 44‑amino-acid GHRH analogue with trans‑3‑hexenoic acid; MW ~5,136 Da. 
2. Clinical endocrinology research: Tesamorelin induces pulsatile GH release via GHRH pathways in obese and metabolic models. J Clin Endocrinol Metab. 2014;99(1):338–343. PMID 24142878. 
3. Peptides.guide entry on MGF: IGF‑1Ec splice variant with tissue-repair effects independent of IGF‑1 receptor. 
4. Schlegel W et al. "MGF (IGF‑1Ec) induces muscle and chondrocyte proliferation via IGF‑1 receptor–independent ERK signaling." PLoS One. 2013;8(10):e76133. PMID 24155902. 
5. PubChem Compound Summary for Ipamorelin (CID 9831659): pentapeptide Aib–His–D‑2‑Nal–D‑Phe–Lys–NH₂; MW 711.9 Da. 
6. Peptides.guide entry on Ipamorelin: selective ghrelin receptor agonist promoting GH release without cortisol/prolactin elevation.