Thymosin Beta 4 (TB500) (10mg)

What is Thymosin Beta 4 (TB500)?

Thymosin Beta 4 (TB4) is a naturally occurring 43–amino-acid peptide abundant in platelets and various tissues, categorized in the β‑thymosin family. TB500 is a synthetic peptide fragment corresponding to amino acids 17–23 (LKKTETQ) within the actin-binding domain of full TB4. It was designed to retain the parent peptide’s key functionalities while offering enhanced tissue penetration and stability for preclinical research into wound healing, angiogenesis, tissue remodeling, and cytoskeletal dynamics.

Chemical Structure of Thymosin Beta 4 (TB500)

• Full-length TB4: A 43–residue peptide with sequence SDKPDMAEIEKFDKS…AGES, molecular formula C₂₁₂H₃₅₀N₅₆O₇₈S, and molecular weight ≈ 4,960 Da (PubChem CID 16132341).
• TB500 fragment: Composed of 7 amino acids Leu–Lys–Lys–Thr–Glu–Thr–Gln (LKKTETQ), with formula C₃₈H₆₈N₁₀O₁₄ and molecular weight ≈ 889 Da (PubChem CID 62707662).

What Are the Effects of Thymosin Beta 4 (TB500)?

• Actin Regulation & Cell Migration: TB4 and its fragment LKKTETQ bind G‑actin to promote actin polymerization, enhancing cellular motility, cytoskeletal organization, and wound-edge migration.
• Angiogenesis & Tissue Remodeling: Both peptides induce expression of angiogenic factors like VEGF and FGF, facilitating vascular sprouting and tissue regeneration in preclinical wound, burn, and ulcer models.
• Anti‑Inflammatory Actions: TB4 modulates inflammatory responses by reducing pro-inflammatory cytokine production and enhancing macrophage-mediated bacterial clearance in keratitis and other tissues.
• Neuroregeneration & Cardioprotection: Preclinical studies demonstrate TB4’s role in neuronal axon regeneration (e.g., zebrafish Mauthner cells), myocardial repair following infarction, and reductions in scarring with enhanced progenitor cell activation.
• Hair Follicle Activation: TB4 accelerates hair follicle activity and hair regrowth in rodent models, likely via angiogenic and cytoskeletal mechanisms in dermal tissues.

Citations

1. PubChem Compound Summary for Thymosin Beta 4 (CID 16132341): Overview of Thymosin Beta 4 and TB500
2. MDPI review: “Thymosin β4 is an endogenous iron chelator… involved in blood clotting, tissue regeneration, angiogenesis, and anti-inflammatory processes.” Overview of Thymosin Beta 4 and TB500
3. PubChem Compound Summary for TB500 fragment (CID 62707662): Overview of Thymosin Beta 4 and TB500
4. BMC Biology: “Thymosin β4 promotes zebrafish Mauthner axon regeneration…” Overview of Thymosin Beta 4 and TB500
5. ScienceDirect Topics: “Thymosin beta-4 promotes angiogenesis, wound repair, and hair growth…” Overview of Thymosin Beta 4 and TB500
6. Frontiers in Immunology: “Activation of pro-resolving pathways mediate the therapeutic effects…” Overview of Thymosin Beta 4 and TB500
7. MDPI: “Thymosin Beta-4 ... improves cardiac function and promotes cell survival…” Overview of Thymosin Beta 4 and TB500
8. Frontiers in Plant Science (Erratum): “Antiapoptotic effects of exogenous thymosin beta‑4…” Overview of Thymosin Beta 4 and TB500
9. Discover Biotechnology: “The combined impact of thymosin beta 4 and selenium on diabetic ulcers.” Overview of Thymosin Beta 4 and TB500
10. MDPI Int J Mol Sci: “Thymosin β4 regulates thymocyte differentiation by G‑actin sequestration…” Overview of Thymosin Beta 4 and TB500