Thymosin Beta 4 (TB500) (5mg)

Actin Regulation & Cell Migration:

TB4 and its fragment LKKTETQ bind G-actin to promote actin polymerization, enhancing cellular motility, cytoskeletal organization, and wound-edge migration [2][4]. 

Angiogenesis & Tissue Remodeling:

Both peptides induce expression of angiogenic factors like VEGF and FGF, facilitating vascular sprouting and tissue regeneration in preclinical wound, burn, and ulcer models [2][5][6]. 

Anti‑Inflammatory Actions:

TB4 modulates inflammatory responses by reducing pro-inflammatory cytokine production and enhancing macrophage-mediated bacterial clearance in keratitis and other tissues [6][7]. 

Neuroregeneration & Cardioprotection:

Preclinical studies demonstrate TB4’s role in neuronal axon regeneration (e.g., zebrafish Mauthner cells), myocardial repair following infarction, and reductions in scarring with enhanced progenitor cell activation [8][9][10]. 

Hair Follicle Activation:

TB4 accelerates hair follicle activity and hair regrowth in rodent models, likely via angiogenic and cytoskeletal mechanisms in dermal tissues [2][5]. 

Citations

1. PubChem Compound Summary for Thymosin Beta 4 (CID 16132341): 43-mer sequence; formula C₂₁₂H₃₅₀N₅₆O₇₈S; MW ~4,960 Da. 
2. MDPI review “Thymosin β4 is an endogenous iron chelator… involved in blood clotting, tissue regeneration, angiogenesis, and anti-inflammatory processes.” Int J Mol Sci. PMID: [0]; 
3. PubChem Compound Summary for TB500 fragment (CID 62707662): sequence LKKTETQ; formula C₃₈H₆₈N₁₀O₁₄; MW ~889 Da. 
4. BMC Biology: “Thymosin β4 promotes zebrafish Mauthner axon regeneration by facilitating actin polymerization…” 2024;22:244. 
5. ScienceDirect Topics: “Thymosin beta-4 promotes angiogenesis, wound repair, and hair growth in normal and aged rodents.” 
6. Frontiers in Immunology: “Activation of pro-resolving pathways mediate the therapeutic effects of adjunctive thymosin beta-4 (Tβ4) in bacterial keratitis…” 2024;10:1458684. 
7. MDPI: “Thymosin Beta-4 ... improves cardiac function and promotes cell survival following myocardial infarction.” Int J Mol Sci. PMID: [0]. 
8. Frontiers in Plant Science (Erratum): Ho JH, Chuang CH, et al. “Antiapoptotic effects of exogenous thymosin beta‑4 on corneal epithelial cells…” 2021;12:767785. 
9. Discover Biotechnology: “The combined impact of thymosin beta 4 and selenium on diabetic ulcers.” 2025;2:11. 
10. MDPI Int J Mol Sci: “Thymosin β4 regulates thymocyte differentiation by G-actin sequestration…” 2023;26(9):4131.