ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

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Thymosin Alpha 1 (TA1) Complex Thymulin (10mg/6.4mg)

Thymosin Alpha 1 (TA1) Complex Thymulin (10mg/6.4mg)

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What is Thymosin Alpha 1 (TA1) Complex Thymulin (10mg/6.4mg)?

This dual-peptide formulation combines two thymic-derived immune modulators: 

  • Thymosin Alpha 1 (TA1) is a 28‑amino‑acid peptide derived from prothymosin‑α. It engages toll-like receptors TLR‑2 and TLR‑9 on dendritic cells and monocytes, enhancing innate and adaptive immune signaling pathways [1][3]. 
  • Thymulin is a naturally occurring nonapeptide (H‑Pyr‑Ala‑Lys‑Ser‑Gln‑Gly‑Gly‑Ser‑Asn‑OH) produced by thymic epithelial cells in a zinc-dependent form. It plays a key role in T-cell differentiation and immune–neuroendocrine regulation [2][4]. 

Combined, these peptides are formulated for preclinical research into immune modulation and neuroendocrine interactions. 

Chemical Structure of Thymosin Alpha 1 (TA1) Complex Thymulin (10mg/6.4mg)

Thymosin Alpha 1 (TA1) is a linear 28‑amino‑acid peptide (Ac‑Ser‑Asp‑Ala‑Ala‑Val‑Asp‑Thr‑Ser‑Ser‑Glu‑Ile‑Thr‑Thr‑Lys‑Asp‑Leu‑Lys‑Glu‑Lys‑Lys‑Glu‑Val‑Val‑Glu‑Glu‑Ala‑Glu‑Asn) with a molecular weight of ~3,108 Da [5]. It is unstructured in solution but adopts amphipathic conformation upon receptor interaction [5]. 

Thymulin is a zinc‑coordinated nonapeptide with the sequence H‑Pyr‑Ala‑Lys‑Ser‑Gln‑Gly‑Gly‑Ser‑Asn‑OH and molecular formula C₃₃H₅₄N₁₂O₁₅ (~806 Da). Zinc binding is essential for its biological activity [2][4]. 

What Are the Effects of Thymosin Alpha 1 (TA1) Complex Thymulin (10mg/6.4mg)?

Immune Modulation via TA1:

Enhances dendritic and monocyte responses, boosting TLR-mediated cytokine production and promoting T-cell differentiation and antiviral defenses [1][3]. 

T‑Cell Maturation & Neuroendocrine Crosstalk from Thymulin:

Zinc-dependent Thymulin supports T-cell maturation, modulates pituitary and hypothalamic functions, and engages neuroendocrine regulation via circadian hormone pathways [2][4]. 

Anti‑Inflammatory Action of Thymulin:

Suppresses NF‑κB activation and reduces pro-inflammatory cytokines, with demonstrated effects in CNS and peripheral inflammation models [4]. 

Synergistic Potential:

The combination enables exploration of adaptive and neuroendocrine immune regulation, including receptor signaling, cytokine biosynthesis, and neuro‑immune feedback in models of immunodeficiency or neuroinflammation. 

Citations

  1. Goldstein AL, et al. “Thymosin α1: Chemistry, mechanism of action and clinical applications.” In: Peptides: Structure and Function (Goldstein ed.), Springer; 2007. 
  2. PeptideBasics – “Characterization of Thymulin: a thymic nonapeptide requiring zinc; regulates T-cell differentiation.” 
  3. PeptideBasics – “Thymosin Alpha‑1: 28‑amino‑acid fragment from prothymosin‑α, functions via TLR‑2 and TLR‑9 on antigen-presenting cells.” 
  4. Lunin SM, Khrenov MO, Novoselova TV, et al. “Thymulin peptide is NF‑κB-dependent and involves IκB‑α downregulation.” Am J Med Biol Res. 2013;1(2):41–49. 
  5. ChemicalBook – Thymosin Alpha‑1: Ac‑Ser‑Asp‑Ala‑…; MW 3108 Da; sequence confirmed by NMR and mass spectrometry. 

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We are continuously conducting HPLC test on all of our raw powders as well as finished products to ensure the quality of our products. You can have the product you bought from us tested at any HPLC licensed testing facility and if the results are negative, we will refund the following:
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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.