ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

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PEG-MGF (5mg)

PEG-MGF (5mg)

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What is PEG-MGF (5mg)?

PEG-MGF, or Pegylated Mechano-Growth Factor, is a synthetic variant of the naturally occurring mechano-growth factor (MGF), a splice variant of the insulin-like growth factor-1 (IGF-1) gene [1][2]. MGF is known for its role in muscle repair and regeneration, particularly in response to mechanical stress or injury [3]. The pegylation process involves attaching polyethylene glycol (PEG) to the MGF peptide, which increases its stability and half-life in biological environments [4]. This structural modification allows PEG-MGF to remain active for longer durations compared to native MGF. Research suggests PEG-MGF may modulate cellular signaling pathways associated with tissue recovery and growth [5].

Chemical Structure of PEG-MGF (5mg)

PEG-MGF is composed of a peptide backbone similar to native MGF but is modified by covalently attaching a PEG group to enhance stability and resistance to enzymatic degradation [4]. A representative sequence of the MGF peptide portion includes PEG-Suc-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-Cys, which reflects its engineered structure for optimal biological activity. This sequence is responsible for its binding affinity to melanocortin-related or IGF-1 pathways, while the PEG moiety ensures an extended circulation time [3]. The PEGylation process does not alter the primary peptide’s mechanism but significantly improves its pharmacokinetic properties. Such design strategies are commonly applied in peptide-based research to enhance stability and efficacy [6].

What Are the Effects of PEG-MGF (5mg)?

PEG-MGF is primarily investigated for its effects on cellular processes related to muscle adaptation and recovery. Studies have shown that MGF can attract stem cells to damaged tissue and reduce apoptosis in myocytes, potentially aiding regeneration [1][6]. The mechano-growth factor component is also involved in regulating inflammatory responses and cytokine activity in muscle tissue [2]. Additionally, MGF has been reported to activate IGF-1 receptor pathways at high concentrations, similar to recombinant human IGF-1 [4]. These properties make PEG-MGF a promising tool for understanding muscle biology, injury response, and cell signaling dynamics [5].

Citations

  1. X. Liu, Z. Zeng, L. Zhao, P. Chen, and W. Xiao, “Impaired Skeletal Muscle Regeneration Induced by Macrophage Depletion Could Be Partly Ameliorated by MGF Injection,” Front. Physiol., vol. 10, p. 601, 2019.
  2. K.-T. Sun, K.-K. Cheung, S. W. N. Au, S. S. Yeung, and E. W. Yeung, “Overexpression of Mechano-Growth Factor Modulates Inflammatory Cytokine Expression and Macrophage Resolution in Skeletal Muscle Injury,” Front. Physiol., vol. 9, 2018.
  3. A. Philippou et al., “Expression of IGF-1 isoforms after exercise-induced muscle damage in humans: characterization of the MGF E peptide actions in vitro,” Vivo Athens Greece, vol. 23, no. 4, pp. 567–575, Aug. 2009.
  4. J. A. M. J. L. Janssen, L. J. Hofland, C. J. Strasburger, E. S. R. van den Dungen, and M. Thevis, “Potency of Full-Length MGF to Induce Maximal Activation of the IGF-I R Is Similar to Recombinant Human IGF-I at High Equimolar Concentrations,” PLoS ONE, vol. 11, no. 3, Mar. 2016.
  5. G. Goldspink, “Research on mechano growth factor: its potential for optimising physical training as well as misuse in doping,” Br. J. Sports Med., vol. 39, no. 11, pp. 787–788, Nov. 2005.
  6. G. Doroudian, J. Pinney, P. Ayala, T. Los, T. A. Desai, and B. Russell, “Sustained delivery of MGF peptide from microrods attracts stem cells and reduces apoptosis of myocytes,” Biomed. Microdevices, vol. 16, no. 5, pp. 705–715, Oct. 2014.

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We are continuously conducting HPLC test on all of our raw powders as well as finished products to ensure the quality of our products. You can have the product you bought from us tested at any HPLC licensed testing facility and if the results are negative, we will refund the following:
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PLUS Total amount of the Order + Shipping Fee

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

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