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Hexarelin (5mg)

Hexarelin (5mg)

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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

What is Hexarelin (5mg)?

Hexarelin (also known as Examorelin or EP‑23905) is a synthetic hexapeptide and a potent agonist of the growth hormone secretagogue receptor (GHS‑R1a), developed from GHRP‑6 by the addition of two methyl groups [1][4]. In research settings, Hexarelin is utilized to study its ability to stimulate growth hormone secretion and to explore its endocrine, metabolic, and cardiovascular effects [2][5][6].

Chemical Structure of Hexarelin (5mg)

Hexarelin has the amino acid sequence His‑D‑Trp(2‑Me)‑Ala‑Trp‑D‑Phe‑Lys‑NH₂, with molecular formula C₄₇H₅₈N₁₂O₆ and average molecular weight of approximately 887 Da, as confirmed by PubChem (CID 6918297) [1][7]. The incorporation of a 2‑methyl tryptophan and D‑amino acids enhances receptor affinity and metabolic stability, while the C-terminal amidation further enhances bioactivity [1][7].

What Are the Effects of Hexarelin (5mg)?

Growth Hormone Release:

Hexarelin significantly increases GH secretion in a dose-dependent manner in both animal and human studies, acting via the ghrelin receptor [2]. 

Pituitary and Adrenal Activation:

In healthy adults, Hexarelin triggers simultaneous release of ACTH and cortisol, likely mediated by arginine vasopressin, while also elevating prolactin levels [5][6]. 

Cardiovascular Effects:

Hexarelin exerts positive inotropic effects — transiently enhancing left ventricular ejection fraction in humans — and binds cardiac CD36 receptors, offering cardioprotective benefits in rodent models independent of GH release [2][5]. 

Appetite and Metabolism:

Research in animal models shows that Hexarelin promotes food intake across age groups and may preserve skeletal muscle via improved mitochondrial biogenesis during metabolic stress [7]. 

Aging and Nutritional State Influence:

The GH response to Hexarelin varies with age and nutritional status; efficacy may decrease in older or well-nourished subjects, while remaining high in younger or undernourished models [5].

Citations

  1. PubChem Compound Summary for Hexarelin (CID 6918297): His‑D‑Trp(2‑Me)‑Ala‑Trp‑D‑Phe‑Lys NH₂; formula C₄₇H₅₈N₁₂O₆; MW ~887 Da. 
  2. Arvat E, Korbonits M, Perry LA, Putignano P, Grossman A, Besser G, Trainer PJ. “Growth Hormone Secretagogue Hexarelin Stimulates the Hypothalamo-Pituitary-Adrenal Axis via Arginine Vasopressin.” J Clin Endocrinol Metab. 1999;84(7):2489–2495. PMID: 10372694. 
  3. Bisi G, Podio V, Valetto MR, Broglio F, Bertuccio G, Del Rio G, Arvat E, Ghigo E. “Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH‑releasing peptide, in humans.” J Endocrinol Invest. 1999;22(4):266–271. PMID: 12796313. 
  4. Locatelli V, et al. “Feeding behavior during long‑term hexarelin administration in young and old rats.” J Endocrinol Invest. 2002;25(10):870–875. PMID: 12501225. 
  5. PubChem Compound Summary confirms structural details and stability. 
  6. Mao Y, Tokudome T, Kishimoto I. “The cardiovascular action of hexarelin.” J Geriatr Cardiol. 2014;11(3):253–258. PMID: 25278975. 
  7. Maghnie M, Spica‑Russotto V, Cappa M, Autelli M, Tinelli C, Civolani P, Deghenghi R, Severi F, Loche S. “The Growth Hormone Response to Hexarelin in Patients with Different Hypothalamic‑Pituitary Abnormalities.” J Clin Endocrinol Metab. 1998;83(11):3886–3889. PMID: 9794861.  

COA

Certificate of Analysis

HPLC

High Performance Liquid Chromatography

High Quality - 99% Purity Guaranteed

Product Quality Guarantee

We are continuously conducting HPLC test on all of our raw powders as well as finished products to ensure the quality of our products. You can have the product you bought from us tested at any HPLC licensed testing facility and if the results are negative, we will refund the following:
HPLC TEST FEE
$100
PLUS Total amount of the Order + Shipping Fee

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

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