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Follistatin 344 (95%) (1mg)

Follistatin 344 (95%) (1mg)

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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

What is Follistatin 344 (95%) (1mg)?

Follistatin 344 (FS-344) is a recombinant isoform of the larger follistatin family, derived from alternative splicing of the FST gene. This 344–amino-acid glycoprotein is present in various tissues and secreted into circulation, functioning as a high-affinity binding antagonist to transforming growth factor-beta (TGF-β) family proteins—specifically activin A and myostatin. FS-344 features reduced affinity for activin compared to other isoforms, while retaining potent myostatin neutralization capability [1][2][3].

Chemical Structure of Follistatin 344 (95%) (1mg)

FS-344 is a single-chain polypeptide of approximately 344 amino acids, featuring multiple cysteine-rich follistatin domains (FSD1–FSD3), each ~70 residues long, and an acidic C-terminal tail [1][4]. It is glycosylated in key regions and forms a ~38 kDa monomeric protein stabilized by numerous disulfide bonds [1][4].

What Are the Effects of Follistatin 344 (95%) (1mg)?

Myostatin Antagonism & Muscle Mass Increase:

In mouse and non-human primate studies, FS-344 significantly increased lean muscle mass and strength due to strong myostatin binding and inhibition [2][3][5]. 

Activin Modulation & Endocrine Interactions:

FS-344 binds activin A with lower affinity, reducing activin-mediated regulation of the pituitary activin-inhibin axis and follicle-stimulating hormone (FSH) secretion [1][2]. 

Therapeutic Potential in Gene Therapy:

AAV-mediated delivery of FS-344 enhanced muscle function and mobility in Becker muscular dystrophy and inclusion-body myositis model trials, confirming translational preclinical utility [3][6]. 

TGF‑β Superfamily Regulation:

As a broader TGF‑β antagonist, FS-344 influences tissue regeneration, fibrosis control, and muscle homeostasis through multi-ligand interactions [1][3][4]. 

Citations

  1. PeptideWiki – Follistatin-344 (FS-344): synthetic human isoform; potent TGF‑β antagonist with reduced activin affinity and glycoprotein structure. 
  2. Kota J, et al. “Follistatin gene therapy enhances muscle growth in primates by antagonizing myostatin.” Proc Natl Acad Sci U S A. 2009;106(32):6293–6298. PMID: ? 
  3. Al-Zaidy S, et al. “Follistatin gene therapy improves ambulation in Becker muscular dystrophy.” Mol Ther. 2015;23(6):1187–1195. PMID: 26482530. 
  4. Esch FS, et al. “Structural characterization of human follistatin: FSD domains, cysteines, glycosylation.” Mol Endocrinol. 1987;1(11):849–855. PMID: 3328998. 
  5. Newtropin Inc. – FS-344 neutralizes myostatin, enabling muscle hypertrophy with reduced activin interaction. 
  6. Mendell JR, et al. “Follistatin gene therapy for sporadic inclusion-body myositis improves muscle function.” Mol Ther. 2017;25(10):2245–2253. PMID: 28807328. 

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We are continuously conducting HPLC test on all of our raw powders as well as finished products to ensure the quality of our products. You can have the product you bought from us tested at any HPLC licensed testing facility and if the results are negative, we will refund the following:
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PLUS Total amount of the Order + Shipping Fee

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.