CJC-1295 - With DAC (10mg)

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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

What is CJC-1295 - With DAC (10mg)?

CJC‑1295 with DAC is a synthetic Growth Hormone–Releasing Hormone (GHRH) analogue modified with a Drug Affinity Complex (DAC) to significantly extend its half-life. Through four amino acid substitutions (D-Ala², Gln⁸, Ala¹⁵, Leu²⁷) and C-terminal DAC conjugation, this peptide maintains high affinity for the GHRH receptor while resisting enzymatic degradation [1][2]. The DAC moiety allows reversible albumin binding, resulting in a half-life of 6–8 days, enabling sustained GH release and reduced dosing frequency in preclinical studies [2][3].

Chemical Structure of CJC-1295 - With DAC (10mg)

CJC‑1295 is a 30-amino-acid peptide analogue of GHRH, with a molecular formula C₁₅₂H₂₅₂N₄₄O₄₂ and a molecular weight of approximately 3,367–3,647 Da [1]. The DAC moiety, linked via maleimidopropionyl-lysine, prolongs peptide stability and systemic exposure by binding to serum albumin and reducing renal clearance [2].

What Are the Effects of CJC-1295 - With DAC (10mg)?

Prolonged GH/IGF‑1 Elevation:

Single administrations in research subjects have shown elevated GH and IGF‑1 levels for up to 6–11 days, compared to hours for standard GHRH analogues [2][3].

Stable Pharmacokinetics:

Albumin binding through DAC allows for consistent plasma levels, making it an ideal candidate for longitudinal GH axis studies [3].

Anabolic & Metabolic Pathways:

Studies demonstrate its ability to enhance protein synthesis, fat metabolism, and nitrogen balance in preclinical models [2].

Citations

PubChem Compound Summary – CJC‑1295 (with DAC) (CID 16129620): molecular formula C₁₅₂H₂₅₂N₄₄O₄₂; MW ~3,367–3,647 Da.
Teichman SL, et al. “Prolonged stimulation of growth hormone (GH) and IGF‑1 secretion by CJC‑1295, a long-acting analog of GHRH, in healthy adults.” J Clin Endocrinol Metab. 2006;91(2):301–307. PMID: 16478914.
Parker DL, et al. “Growth hormone–releasing factor-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC‑1295 as a long-lasting GRF analog.” Endocrinology. 2005;146(7):2442–2449. PMID: 15738487.

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We are continuously conducting HPLC test on all of our raw powders as well as finished products to ensure the quality of our products. You can have the product you bought from us tested at any HPLC licensed testing facility and if the results are negative, we will refund the following:
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CJC-1295 - With DAC (10mg)