Cardiogen (25mg)

Cardiac Tissue Effects:

In organotypic rat heart cultures, Cardiogen stimulated cardiomyocyte proliferation in both young and aged tissue, often accompanied by decreased p53 expression—suggesting reduced apoptosis [2][3]. 

Fibroblast Regulation:

Studies show Cardiogen alters fibroblast behavior, increasing collagen and elastin synthesis—key elements in tissue maintenance and repair [6]. 

Tumor-Cell–Selective Apoptosis:

In rat M-1 sarcoma models, Cardiogen induced apoptosis in tumor tissue, attributed to vascular-mediated mechanisms, while preserving healthy cardiac tissue [4]. 

Intracellular Protein Upregulation:

Investigations reveal Cardiogen increases expression of cytoskeletal proteins (actin, vimentin, tubulin) and nuclear matrix proteins (lamins A/C), which may support cell growth and stability [6]. 

Potential Anti-Apoptotic Activity:

Laboratory observations indicate that Cardiogen may inhibit apoptosis via downregulation of p53 and enhancement of structural protein synthesis [2][6]. 

Citations

1. PubChem Compound Summary for Cardiogen (CID 11583989), molecular formula and weight. 
2. Chalisova NI, Lesniak VV, Balykina NA, Urt’eva SA, Urt’eva TA, Sukhonos IuA, Zhekalov AN. The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats. Adv Gerontol. 2009;22(3):409–13. PMID: 20210190. 
3. Levdik NV, Knyazkin IV. Tumor‑modifying effect of cardiogen peptide on M‑1 sarcoma in senescent rats. Bull Exp Biol Med. 2009 Sep;148(3):433–6. PMID: 20396706. 
4. Kheĭfets OV, Poliakova VO, Kvetnoĭ IM. Peptidergic regulation of the expression of signal factors of fibroblast differentiation in the human prostate gland in cell aging. Adv Gerontol. 2010;23(1):68–70. PMID: 20586252. 
5. PubChem Compound Summary for Cardiogen (CID 11583989) confirms formula C₁₈H₃₁N₇O₉, MW 489.5. 
6. Khavinson VKh, Fedoreyeva LI, Vanyushin BF. Site‑specific binding of short peptides with DNA modulated eukaryotic endonuclease activity. Bull Exp Biol Med. 2011 May;151(1):66–72. PMID: 22442805.