BPC-157 (5mg)

What is BPC‑157?

BPC‑157 (Body Protection Compound‑157) is a research-grade, synthetic 15‑amino‑acid peptide originally identified in human gastric juice and later synthesized for laboratory studies. Unlike many endocrine-related peptides, it's primarily examined for its potential in tissue repair, inflammation modulation, and protective mechanisms across multiple organ systems.

Chemical Structure of BPC‑157

This pentadecapeptide has the sequence: Gly–Glu–Pro–Pro–Pro–Gly–Lys–Pro–Ala–Asp–Asp–Ala–Gly–Leu–Val, with a molecular formula of C₆₂H₉₈N₁₆O₂₂ and molecular weight approximately 1,419.5 Da. It is stable under room temperature and demonstrates resilience in gastric conditions, making it viable for various routes of administration in experimental models.

What Are the Effects of BPC‑157?

• Tissue Regeneration & Wound Healing: Preclinical studies in rodents report accelerated healing of tendons, ligaments, skin wounds, and muscle injuries, correlating with increased fibroblast growth, collagen synthesis, and angiogenesis.
• Gastrointestinal Protection: Demonstrated anti‑ulcer and cytoprotective effects in gastric injury models, with regulated villus‑crypt structure and intestinal tissue preservation.
• Angiogenesis & Vascular Repair: Stimulates vascular endothelial growth factor (VEGF) signaling and nitric oxide pathways, promoting blood vessel formation in ischemic and injury models.
• Neuro‑ & Organ‑Protection: Experimental findings suggest BPC‑157 mitigates brain and nerve injury, maintains liver and kidney integrity under toxic stress, and reduces inflammatory markers.
• Anti‑Inflammatory & Oxidative Stress Reduction: Modulates nitric oxide and inflammatory cytokines, displaying both antioxidant and analgesic effects in animal research.
• Safety Profile: To date, studies report low toxicity and no significant adverse immunogenic or endocrine reactions under laboratory conditions.

Citations

1. PubChem, “BPC‑157 Compound Summary,” NCBI PubChem, CID 9941957. BPC‑157 Molecular Structure
2. Peptide Sciences, “What is BPC‑157 Peptide?” BPC‑157 Molecular Structure
3. Seiwerth S, et al. “Stable Gastric Pentadecapeptide BPC‑157 and Wound Healing.” Front Pharmacol. 2021;12:627533. BPC‑157 Molecular Structure
4. Staresinic M, et al. “BPC‑157 accelerates healing of rat Achilles tendon.” J Orthop Res. 2003;21(6):976–983. BPC‑157 Molecular Structure
5. Chang CH, et al. “BPC‑157 promotes tendon healing.” J Appl Physiol. 2011;110(3):774–780. BPC‑157 Molecular Structure
6. “Stable gastric pentadecapeptide BPC‑157: GI therapy.” Curr Pharm Des. 2011. BPC‑157 Molecular Structure
7. “BPC‑157 promotes angiogenesis via VEGFR2 and NO.” BPC‑157 Molecular Structure
8. Peptides.org, “BPC‑157 Reviews and Safety.” BPC‑157 Molecular Structure
9. Cerovecki T, et al. “BPC‑157 improves ligament healing in rats.” J Orthop Res. 2010;28(9):1155–1161. BPC‑157 Molecular Structure